https://www.latimes.com/science/story/2020-04-17/malaria-drugs-fails-to-help-coronavirus-patients-in-controlled-studies
Malaria drugs fail to help coronavirus patients in controlled studies
By MELISSA HEALYSTAFF WRITER
APRIL 17, 20203:08 PM
抗マラリヤ薬のクロロキン、ヒドロキシクロロキンは中国、仏蘭西とブラジルの臨床テストで
好ましい結果が得られていない

The malaria drugs touted by President Trump as potentially “the biggest game
changers in the history of medicine” have received a decidedly more sober
assessment of their coronavirus-fighting potential from researchers in China,
France and Brazil.

Both chloroquine and its close relative hydroxychloroquine offered signs that
they may ease some of the hallmark symptoms of coronavirus infection in
patients who were hospitalized with COVID-19. But the drugs largely failed to
deliver improvements on other key measures when evaluated in rigorous research
studies.

In research done in France, hydroxychloroquine reduced neither deaths nor
admissions to intensive care units among patients who received it. In a study
conducted in China and another in Brazil, the two drugs failed to help patients
clear the coronavirus faster.

And in Brazil, two deaths and a rash of heart troubles among patients who got
a high dose of chloroquine prompted a hasty alteration of the trial there after
just 13 days. Concluding that “enough red flags” had been raised, the
researchers halted testing of the drug in its extra-strength form.（ry